ISPOR 2025 posters: Exclusive author insights

A graphical evidence framework is a visual map to organise and present evidence in a clear and systematic way. It typically shows key claims, supporting evidence, relationships and gaps or uncertainties. Instead of presenting evidence in long lists or tables, it organizes information into a diagram that shows how different pieces of evidence connect to outcomes, interventions, and stakeholder priorities. A graphical evidence framework makes complex evidence easier to understand at a glance, helps identify which claims or value drivers are robustly supported and which need more research. We presented Alzheimer’s disease as an example. Managing Alzheimer’s involves many stakeholders including patients, caregivers, clinicians, payers, and policymakers, each with different priorities (e.g., quality of life, cost, caregiver burden). Evidence exists across multiple domains: clinical outcomes, economic impact, social implications, and quality-of-life measures. We mapped these domains visually, showing how interventions (like new therapies or care models) influence each area. The map highlighted gaps where evidence is missing (e.g., long-term caregiver outcomes) and showed interconnections (e.g., improving cognition might reduce hospitalizations and costs).

The value of this using this approach is:

• Clarity: Makes complex evidence easier to understand at a glance
• Holistic view: Captures system-level relationships, not just isolated outcomes
• Stakeholder alignment: Shows how different priorities intersect, helping decision-makers see the bigger picture.
• Identifies gaps: Reveals where more research is needed
• Supports better decisions: Informs policy, research planning, and resource allocation by showing the full impact of interventions

Graphical evidence frameworks support the growing need to capture the broader, system-level impact of health interventions rather than focusing on isolated outcomes. By visualizing value drivers and stakeholder perspectives across the healthcare ecosystem, the framework can help researchers and policymakers understand the bigger picture, set priorities, and design strategies that reflect real-world complexity.

If you have any questions or would like to hear more about our research please contact James Dennis, Senior Medical Writer at HEOR: james.dennis@heor.co.uk.