AI was everywhere at ISPOR 2026, but the conversation has matured well past the hype. In this final episode of the series, Phil and Marc look at where agentic AI and large language models are genuinely changing HEOR practice — from AI-assisted systematic literature reviews to frameworks for evaluating AI use in submissions. They also examine NICE’s emerging position on AI-generated evidence, and ask the question every health economist is quietly asking: how much of this work will still need a human in five years’ time?