Mount Hood Challenge 2022


Carrie Fidler | 

Phil McEwan and Volker Foos will be participating in the Mount Hood Challenge 2022.
Mount Hood Challenge meetings are open forums for computer modelers of diabetes to discuss and compare models. These forums allow modelers to identify important differences observed between predicted model outputs when using standardised inputs; discuss methodological challenges and agree on approaches to improving diabetes models. The challenges are developed collectively by an international group of researchers engaged in development of diabetes simulation models for health economic evaluation. For 2022 the challenges are:

    • Challenge 1: Revisiting the Mount Hood reference case for type 1 & type 2 diabetes
    • Challenge 2: Costs & cost-effectiveness of common treatments for diabetes

The Cardiff Diabetes Model

The Cardiff Diabetes Model, developed by the HEOR team, is a fixed-time increment stochastic simulation model to evaluate the impact of therapeutic intervention in type 1 and type 2 diabetes.

The model has been used to explore general health economic issues in diabetes modelling including the cost effectiveness of treatment strategies; the inter-relationship of haemoglobin A1c (HbA1c), hypoglycaemia and weight change on predicted quality adjusted life years; and the influence of therapy escalation thresholds on cost-effectiveness. The Cardiff model has participated in the last ten Mount Hood Challenge meetings.

The model is designed to evaluate a treatment and control pathway, each of which are comprised of up to three lines of therapy. Therapy escalation is either time dependent or controlled via user-defined HbA1c thresholds. Model output includes the incidence of microvascular and macrovascular complications, hypoglycaemia, diabetes-specific mortality and all-cause mortality and point estimates of costs, life years and quality-adjusted life years.

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